Engineering on the Small Scale
Ph.D. Candidate in Mechanical Engineering
The Ohio State University
DNA nanotechnology, specifically DNA origami, enables the precise fabrication of nanoscale geometries. Here, we demonstrate an approach to engineer complex and reversible motion of DNA origami mechanisms.
Following a traditional macroscopic machine design approach, we developed nanoscale kinematic rotational and linear joints that integrate stiff double-stranded DNA components and flexible single-stranded DNA components to constrain motion along a single degree of freedom and demonstrate the ability to tune flexibility and range of motion. Multiple joints were then integrated into various higher order mechanisms including a crank–slider that couples rotational and linear motion.
We have also demonstrated multiple actuation methods to achieve reversible conformational changes via input DNA strands to form new connections distributed throughout the mechanisms. We have recently developed another actuation method using weakly complementary DNA connections that can that can be controlled by adjusting cation concentration. We expect these approaches can increase actuation rates because they do not rely on a competitive strand displacement process.
Our results provide a framework for controllable 2D and 3D DNA-based mechanisms and materials that could be used for measuring biomolecules, biosensing, and triggered drug delivery.
About the Speaker:
Alex Marras grew up in Columbus and earned his B.S. (2011) and M.S. (2013) degrees in Mechanical Engineering at The Ohio State University. He was a member of TBDBITL while an undergrad. He is currently working on his Ph.D. in Mechanical Engineering under the guidance of Assist. Prof. Carlos Castro and expects to finish this coming summer. He received the 2016 Presidential Fellowship – the most prestigious award given by the Graduate School – recognizing outstanding scholarly accomplishments and potential of students entering the final phase of their dissertation research.
5:00 – 6:00 PM
Executive Meeting-All members welcome
6:00 – 7:00 PM
Adult beverages available
7:00 – 7:45 PM
Garden Salad-Greens topped with tomatoes, cucumbers, and red onions
Beef Stroganoff-Tender beef, mushrooms and onions braised in a red wine demi-glace, topped with a dollop of sour cream.
Pork Wiener Schnitzel-Lightly breaded cutlet cooked to a delicate golden brown.
Redskin Mashed Potatoes
(Special diet option also available)
Beverages-water, coffee, tea, and soft drinks
7:45 – 8:45 PM
DNA Origami: Engineering on the Small Scale
$20 for members, $25 for non-members, $5 for retired and unemployed members, $5 per student. Payment will be collected at the door. Cash and checks accepted. There is no cost to attend the program only. Remember that this is a dinner order and must be paid. Please help control costs by honoring your order.
|Reservation Deadline||Thursday, February 9, 2017 at 5:00 pm|
|Program Contact||James J. Wasil, 614-271-5970 firstname.lastname@example.org|
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