Columbus Section

of the American Chemical Society

Tuesday May 15, 2018 Meeting Announcement

Columbus Section Award & Presentation

Drugging Undruggable Targets with Macrocyclic Peptides  

by Award Recipient and Speaker

Dr. Dehua Pei

Kimberly Professor, The Ohio State University

Meeting Location: Ohio Dominican University

Bishop James A. Griffin Student Center (Room #259/260) 

1216 Sunbury Road

Columbus, OH 43219 

About our speaker

Dr. Dehua Pei is a Kimberly Professor at the Department of Chemistry and Biochemistry at the Ohio State University. He has been a faculty at OSU since 1995.

Dr. Pei obtained his B.S. degree in Chemistry from Wuhan University, China in 1986. He received his Ph.D. degree in organic chemistry from University of California, Berkeley in 1991. After receiving his Ph.D. he worked with Dr. Christopher T. Walsh at Harvard Medical School for a stint as postdoctoral fellow prior to joining the Department of Chemistry and Biochemistry at OSU in 1995.

Dr. Pei has been a pioneering researcher in his field. He was elected as a Fellow of the American Association for the Advancement of Science in 2010 for his contributions in his field of research. 

Presentation Abstract

The majority (~80%) of disease-relevant human proteins, including most of those involved in intracellular protein-protein interactions (PPIs), are undruggable by the current drug modalities, namely small molecules (MW<500) and biologics (MW>5000). I will discuss our efforts on developing molecules in the "middle space" (MW 500-2000; e.g., macrocyclic peptides) to target intracellular proteins. We first developed a combinatorial library technology to discover macrocyclic peptidyl ligands that bind to a protein target of interest with antibody-like affinity and specificity. We next discovered a family of small, amphipathic cyclic peptides as a novel class of exceptionally active cell-penetrating peptides and elucidated their mechanism of action. Finally, by integrating the two platform technologies, we have designed potent, selective, cell-permeable, and metabolically stable macrocyclic peptidyl inhibitors against a wide variety of intracellular enzymes (e.g., Pin1 and PTP1B) and PPIs (e.g., calcineurin-NFAT, CFTR-associated ligand-CFTR, K-Ras-Raf, and NEMO-IKK interactions).

Program Details

5:00-6:00 PMACS Executive Committee Meeting-All members welcome
6:00-6:30 PMCheck-in and Social Hour-Cash bar available
6:30-7:15 PM


Chinese Slaw

Chicken Stir Fry

Seasoned Rice

Side of Vegetables 

Drinks– Tea, Coffee, Iced Tea, Water, Soft Drinks

Cash Bar (6-7 pm)-Wine and Beer 

7:15-7:30 PM

Columbus Section Award Presentation:

Award Recipient: Dr. Dehua Pei, Professor, OSU

7:30-8:15 PMPresentation- Drugging Undruggable Targets with Macrocyclic Peptides
8:15-8:30 PMClosing Remarks, if any

ACS Members: $20 per person. Non-members: $25 per person. $5 for retired, emeritus, and unemployed section members and students. Payment will be collected at the door.  Cash and checks accepted.  There is no cost to attend the program only. Dinner cost will be waived for new members who joined the local section in 2017 and 2018 when they attend their first local section meeting. Remember that this is a dinner order and must be paid.  Please help control costs by honoring your order.

RSVPPlease send an e-mail to providing the information listed below.
E-mail Reservations


  • First and last name
  • Membership category: member, non-member, retired, emeritus, unemployed, student.
  • Employer, if applicable
  • Indicate if you will join us for Dinner & Program or Program-Only
  • Indicate if you are a new member and attending Columbus section events for the 1st time, if applicable


Reservation Deadline
Monday, May 14, 2018 at 5:00 p.m.
Program Contact
Bob Kroshefsky,


FREE PARKING at Gold Lot near Alumni Hall

Click here to use google maps for directions


From the East – Take I-70 West to exit 100 B for Fourth Street (toward US 23 North).  Turn right onto South 4th Street.  Turn left onto West Broad Street.  Restaurant will be on your left just beyond COSI between the railroad trestles.


From the West – Take I-70 East to Exit 97 for US 40/West Broad Street.  Turn left onto US 40 (West Broad Street).  Restaurant will be on your right between the railroad trestles.  If you see COSI, you’ve gone too far!


From the South – Take I-71 North to exit 106A/106B on the left and merge onto OH 315 North.  Take US 62/OH 3/Rich Street exit toward Town Street.  Turn right onto OH 3/US 62/West Rich Street.  Turn left at the 3rd cross street onto South Gift Street.  Turn right onto West Broad Street.  The restaurant will be on your right between the railroad trestles.  If you see COSI, you’ve gone too far