Columbus Section Award & Presentation
Drugging Undruggable Targets with Macrocyclic Peptides
by Award Recipient and Speaker
Dr. Dehua Pei
Kimberly Professor, The Ohio State University
Meeting Location: Ohio Dominican University
Bishop James A. Griffin Student Center (Room #259/260)
Dr. Pei obtained his B.S. degree in Chemistry from Wuhan University, China in 1986. He received his Ph.D. degree in organic chemistry from University of California, Berkeley in 1991. After receiving his Ph.D. he worked with Dr. Christopher T. Walsh at Harvard Medical School for a stint as postdoctoral fellow prior to joining the Department of Chemistry and Biochemistry at OSU in 1995.Dr. Pei has been a pioneering researcher in his field. He was elected as a Fellow of the American Association for the Advancement of Science in 2010 for his contributions in his field of research.
The majority (~80%) of disease-relevant human proteins, including most of those involved in intracellular protein-protein interactions (PPIs), are undruggable by the current drug modalities, namely small molecules (MW<500) and biologics (MW>5000). I will discuss our efforts on developing molecules in the "middle space" (MW 500-2000; e.g., macrocyclic peptides) to target intracellular proteins. We first developed a combinatorial library technology to discover macrocyclic peptidyl ligands that bind to a protein target of interest with antibody-like affinity and specificity. We next discovered a family of small, amphipathic cyclic peptides as a novel class of exceptionally active cell-penetrating peptides and elucidated their mechanism of action. Finally, by integrating the two platform technologies, we have designed potent, selective, cell-permeable, and metabolically stable macrocyclic peptidyl inhibitors against a wide variety of intracellular enzymes (e.g., Pin1 and PTP1B) and PPIs (e.g., calcineurin-NFAT, CFTR-associated ligand-CFTR, K-Ras-Raf, and NEMO-IKK interactions).
|5:00-6:00 PM||ACS Executive Committee Meeting-All members welcome|
|6:00-6:30 PM||Check-in and Social Hour-Cash bar available|
Chicken Stir Fry
Side of Vegetables
Drinks– Tea, Coffee, Iced Tea, Water, Soft Drinks
Cash Bar (6-7 pm)-Wine and Beer
Columbus Section Award Presentation:
Award Recipient: Dr. Dehua Pei, Professor, OSU
|7:30-8:15 PM||Presentation- Drugging Undruggable Targets with Macrocyclic Peptides|
|8:15-8:30 PM||Closing Remarks, if any|
ACS Members: $20 per person. Non-members: $25 per person. $5 for retired, emeritus, and unemployed section members and students. Payment will be collected at the door. Cash and checks accepted. There is no cost to attend the program only. Dinner cost will be waived for new members who joined the local section in 2017 and 2018 when they attend their first local section meeting. Remember that this is a dinner order and must be paid. Please help control costs by honoring your order.
|RSVP||Please send an e-mail to firstname.lastname@example.org providing the information listed below.|
|Reservation Deadline||Monday, May 14, 2018 at 5:00 p.m.|
|Program Contact||Bob Kroshefsky, Emailemail@example.com|
FREE PARKING at Gold Lot near Alumni Hall